Original Articles

2026

Takemura A, Egawa T, Takagi R, Zhao H, Iyama R, Suzuki S, Fujino R, Fukunaga T, Hayashi T, Fujita S.

Mild hyperbaric oxygen enhanced the regeneration of the tibialis anterior muscle after the cardiotoxin-induced muscle injury.
Biochem Biophys Rep. in press.
 

2025

Takemura A, Egawa T, Uemichi K, Iyama R, Oba M, Hayashi T, Fujita S.
Mild hyperbaric oxygen does not attenuate mitochondrial decrease induced by detraining in mice.
Biochem Biophys Rep. 2025;44:102341.
https://doi.org/10.1016/j.bbrep.2025.102341

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Suzuki S, Fukunaga T, Hayashi T, Egawa T.
HRasV12 induces apoptosis, not cellular senescence in mouse skeletal myoblasts.
Mech Ageing Dev. 2025;225:112066.
https://doi.org/10.1016/j.mad.2025.112066

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Takemura A, Egawa T, Takagi T, Iyama R, Zhao H, Suzuki S, Fujino R, Fukunaga T, Hayashi T, Fujita S.
Mild hyperbaric oxygen enhances recovery of the plantaris muscle atrophy induced by cast immobilization of the hindlimb in male rats.
Physiol Rep. 2025;13(9):e70350.
https://doi.org/10.14814/phy2.70350

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2024

Suzuki S, Hayashi T, Egawa T.
Advanced glycation end products promote ROS production via PKC/p47 phox axis in skeletal muscle cells.
J Physiol Sci. 2024;74(1):51.
https://doi.org/10.1186/s12576-024-00944-1

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Zhao H, Iyama R, Kurogi E, Hayashi T, Egawa T.
Direct and acute effects of advanced glycation end products on proteostasis in isolated mouse skeletal muscle.
Physiol Rep. 2024:e16121.
https://doi.org/10.14814/phy2.16121

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Egawa T, Ogawa T, Yokokawa T, Kido K, Iyama R, Zhao H, Kurogi E, Goto K, Hayashi T.
Glycative stress inhibits hypertrophy and impairs cell membrane integrity in overloaded mouse skeletal muscle.
J Cachexia Sarcopenia Muscle. 2024;15(3):883–896.
https://doi.org/10.1002/jcsm.13444

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2023

Suzuki S, Hayashi T, Egawa T.
Advanced glycation end products inhibit proliferation and primary cilia formation of myoblasts through receptor for advanced glycation end products pathway.
Biochem Biophys Res Commun. 2023;684:149141.
https://doi.org/10.1016/j.bbrc.2023.149141

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2022

Kido K, Egawa T, Watanabe S, Kawanaka K, Treebak J, Hayashi T.
Fasting potentiates insulin-mediated glucose uptake in rested and prior-contracted rat skeletal muscle.
Am J Physiol Endocrinol Metab. 2022;322(5):E425–E435.
https://doi.org/10.1152/ajpendo.00412.2021

 

Fujiyoshi H, Egawa T, Yokokawa T, Kido K, Hayashi T.
TLR4-mediated inflammatory responses regulate exercise-induced molecular adaptations in mouse skeletal muscle.
Int J Mol Sci. 2022;23(3):1877.
https://doi.org/10.3390/ijms23031877

 

Egawa T, Ogawa T, Yokokawa T, Kido K, Goto K, Hayashi T.
Methylglyoxal reduces molecular responsiveness to 4 weeks of endurance exercise in mouse plantaris muscle.
J Appl Physiol. 2022;132(2):477–488.
https://doi.org/10.1152/japplphysiol.00539.2021

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2021

Kido K, Egawa T, Fujiyoshi H, Suzuki H, Kawanaka K, Hayashi T.
AMPK is indispensable for overload-induced muscle glucose uptake and glycogenesis but dispensable for inducing hypertrophy in mice.
FASEB J. 2021;35:e21459.
https://doi.org/10.1096/fj.202002164R

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2020

Yokoyama S, Ohno Y, Egawa T, Ohashi K, Ito R, Quiroga HPO, Yamashita T, Goto K.
MBNL1-associated mitochondrial dysfunction and apoptosis in C2C12 myotubes and mouse skeletal muscle.
Int J Mol Sci. 2020;21(17):6376.
https://doi.org/10.3390/ijms21176376

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Egawa T, Kido K, Yokokawa T, Fujibayashi M, Goto K, Hayashi T.
Involvement of receptor for advanced glycation end products in microgravity-induced skeletal muscle atrophy in mice.
Acta Astronaut. 2020;176:332–340.
https://doi.org/10.1016/j.actaastro.2020.07.002

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Takemura A, Pajevic PD, Egawa T, Teshigawara R, Hayashi T, Ishihara A.
Effects of mild hyperbaric oxygen on osteoporosis in rats induced by hindlimb unloading.
J Bone Miner Metab. 2020;38(5):631–638.
https://doi.org/10.1007/s00774-020-01100-6

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2019

Egawa T, Ohno Y, Yokoyama S, Yokokawa T, Tsuda S, Goto K, Hayashi T.
The protective effect of Brazilian propolis against glycation stress in mouse skeletal muscle.
Foods. 2019;8(10):439.
https://doi.org/10.3390/foods8100439

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Takemura A, Egawa T, Tanaka T, Kuramoto T, Hayashi T, Ishihara A.
Effects of exposure to mild hyperbaric oxygen on DSS-induced colonic inflammation and diarrhea in rats.
J Inflamm Res. 2019;12:293–299.
https://doi.org/10.2147/JIR.S220586

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Tsuda S, Hayashi T, Egawa T.
The effects of caffeine on metabolomic responses to muscle contraction in rat skeletal muscle.
Nutrients. 2019;11(8):1819.
https://doi.org/10.3390/nu1108181

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Ohno Y, Egawa T, Yokoyama S, Fujiya H, Sugiura T, Ohira Y, Yoshioka T, Goto K.
MENS-associated increase of muscular protein content via modulation of caveolin-3 and TRIM72.
Physiol Res. 2019;68(2):265–273.
https://doi.org/10.33549/physiolres.933992

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Ohno Y, Ando K, Ito T, Suda Y, Matsui Y, Oyama A, Kaneko H, Yokoyama S, Egawa T, Goto K.
Lactate stimulates a potential for hypertrophy and regeneration of mouse skeletal muscle.
Nutrients. 2019;11(4):869.
https://doi.org/10.3390/nu11040869

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2018

Ito R, Higa M, Goto A, Aoshima M, Ikuta A, Ohashi K, Yokoyama S, Ohno Y, Egawa T, Miyata H, Goto K.
Activation of adiponectin receptors has negative impact on muscle mass in C2C12 myotubes and fast-type mouse skeletal muscle.
PLoS One. 2018;13(10):e0205645.
https://doi.org/10.1371/journal.pone.0205645

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Egawa T, Ohno Y, Goto A, Yokoyama S, Hayashi T, Goto K.
AMPK mediates muscle mass change but not the transition of myosin heavy chain isoforms during unloading and reloading of skeletal muscles in mice.
Int J Mol Sci. 2018;19(10):2954.
https://doi.org/10.3390/ijms19102954

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Egawa T, Ohno Y, Yokoyama S, Goto A, Ito R, Hayashi T, Goto K.
The effect of advanced glycation end products on cellular signaling molecules in skeletal muscle.
J Phys Fit Sports Med. 2018;7(4):229–238.
https://doi.org/10.7600/jpfsm.7.229

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Ohno Y, Oyama A, Kaneko H, Egawa T, Yokoyama S, Sugiura T, Ohira Y, Yoshioka T, Goto K.
Lactate increases myotube diameter via activation of MEK/ERK pathway in C2C12 cells.
Acta Physiol. 2018;223(2):e13042.
https://doi.org/10.1111/apha.13042

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Goto A, Sekine K, Oshima R, Sakon I, Iwamoto M, Osaki T, Haga K, Hayashi T, Egawa T.
The effect of short-term heat stress on protein synthesis signaling in isolated rat skeletal muscle.
J Phys Fit Sports Med. 2018;7(1):87–93.
https://doi.org/10.7600/jpfsm.7.87

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2017

Egawa T, Tsuda S, Goto A, Yokoyama S, Ohno Y, Goto K, Hayashi T.
Potential involvement of dietary advanced glycation end products in impairment of skeletal muscle growth and muscle contractile function in mice.
Br J Nutr. 2017;117(1):21–29.
https://doi.org/10.1017/S0007114516004591

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2016

Yokoyama S, Ohno Y, Egawa T, Yasuhara K, Nakai A, Sugiura T, Ohira Y, Yoshioka T, Okita M, Origuchi T, Goto K.
Heat shock transcription factor 1-associated expression of slow myosin heavy chain in mouse soleus muscle in response to unloading with or without reloading.
Acta Physiol. 2016;217(4):325–337.
https://doi.org/10.1111/apha.12692

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Egawa T, Ohno Y, Goto A, Sugiura T, Ohira Y, Yoshioka T, Hayashi T, Goto K.
Caffeine affects myotube size as well as regulates protein degradation and protein synthesis pathways in C2C12 skeletal muscle cells.
J Caffeine Res. 2016;6(2):88–96.
https://doi.org/10.1089/jcr.2015.0034

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2015

Ohno Y, Egawa T, Yokoyama S, Nakai A, Sugiura T, Ohira Y, Yoshioka T, Goto K.
Deficiency of heat shock transcription factor 1 suppresses heat stress-associated increase in slow soleus muscle mass of mice.
Acta Physiol. 2015;215(4):191–203.
https://doi.org/10.1111/apha.12600

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Goto A, Egawa T, Sakon I, Oshima R, Ito K, Serizawa Y, Sekine K, Tsuda S, Goto K, Hayashi T.
Heat stress acutely activates insulin-independent glucose transport and 5'-AMP-activated protein kinase prior to an increase in HSP72 in rat skeletal muscle.
Physiol Rep. 2015;3(11):e12601.
https://doi.org/10.14814/phy2.12601

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Tsuda S, Egawa T, Kitani K, Oshima R, Ma X, Hayashi T.
Caffeine and contraction synergistically stimulate 5'-AMP-activated protein kinase and insulin-independent glucose transport in rat skeletal muscle.
Physiol Rep. 2015;3(10):e12592.
https://doi.org/10.14814/phy2.12592

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Egawa T, Goto A, Ohno Y, Yokokawa T, Ikuta A, Suzuki M, Sugiura T, Ohira Y, Yoshioka T, Hayashi T, Goto K.
Involvement of AMPK in regulating slow-twitch muscle atrophy during hindlimb unloading in mice.
Am J Physiol Endocrinol Metab. 2015;309(7):E651–E662.
https://doi.org/10.1152/ajpendo.00165.2015

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Oshima R, Yamada M, Kurogi K, Ogino Y, Serizawa Y, Tsuda S, Ma X, Egawa T, Hayashi T.
Evidence for organic cation transporter-mediated metformin transport and 5'-adenosine monophosphate-activated protein kinase activation in rat skeletal muscles.
Metabolism. 2015;64(2):296–304.
https://doi.org/10.1016/j.metabol.2014.10.037

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2014

Egawa T, Ohno Y, Goto A, Ikuta A, Suzuki M, Ohira T, Yokoyama S, Sugiura T, Ohira Y, Yoshioka T, Goto K.
AICAR-induced activation of AMPK negatively regulates myotube hypertrophy through HSP72-mediated pathway in C2C12 skeletal muscle cells.
Am J Physiol Endocrinol Metab. 2014;306(3):E344–E354.
https://doi.org/10.1152/ajpendo.00495.2013

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2013

Goto A, Ohno Y, Ikuta A, Suzuki M, Ohira T, Egawa T, Sugiura T, Yoshioka T, Ohira Y, Goto K.
Up-regulation of adiponectin expression in antigravitational soleus muscle in response to unloading followed by reloading, and functional overloading in mice.
PLoS One. 2013;8(12):e81929.
https://doi.org/10.1371/journal.pone.0081929

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Miyamoto L, Egawa T, Oshima R, Kurogi E, Tomida Y, Tsuchiya K, Hayashi T.
AICAR stimulation metabolome-widely mimics electrical contraction in isolated rat epitrochlearis muscle.
Am J Physiol Cell Physiol. 2013;305(12):C1214–C1222.
https://doi.org/10.1152/ajpcell.00162.2013

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Koya T, Nishizawa S, Ohno Y, Goto A, Ikuta A, Suzuki M, Ohira T, Egawa T, Nakai A, Sugiura T, Ohira Y, Yoshioka T, Beppu M, Goto K.
Heat shock transcription factor 1-deficiency attenuates overloading-associated hypertrophy of mouse soleus muscle.
PLoS One. 2013;8(10):e77788.
https://doi.org/10.1371/journal.pone.0077788

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Nishizawa S, Koya T, Ohno Y, Goto A, Ikuta A, Suzuki M, Ohira T, Egawa T, Nakai A, Sugiura T, Ohira Y, Yoshioka T, Beppu M, Goto K.
Regeneration of injured skeletal muscle in heat shock transcription factor 1-null mice.
Physiol Rep. 2013;1(3):e00071.
https://doi.org/10.1002/phy2.71

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Ma X, Tsuda S, Yang X, Gu N, Tanabe H, Oshima R, Matsushita T, Egawa T, Dong A, Zhu B, Hayashi T.
Pu-erh tea hot water extract activates Akt and induces insulin-independent glucose transport in rat skeletal muscle.
J Med Food. 2013;16(3):259–262.
https://doi.org/10.1089/jmf.2012.2520

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2012

Egawa T, Masuda S, Goto K, Hayashi T.
Increased dystrophin mRNA and protein levels in atrophic skeletal muscles in streptozotocin-induced diabetic rat.
J Phys Fit Sports Med. 2012;1(4):709–713.
https://doi.org/10.7600/jpfsm.1.709

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Tsuda S, Egawa T, Ma X, Oshima R, Kurogi E, Hayashi T.
Coffee polyphenol caffeic acid but not chlorogenic acid increases 5'AMP-activated protein kinase and insulin-independent glucose transport in rat skeletal muscle.
J Nutr Biochem. 2012;23(11):1403–1409.
https://doi.org/10.1016/j.jnutbio.2011.09.001

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2011

Egawa T, Tsuda S, Ma X, Hamada T, Hayashi T.
Caffeine modulates phosphorylation of insulin receptor substrate-1 and impairs insulin signal transduction in rat skeletal muscle.
J Appl Physiol. 2011;111(6):1629–1636.
https://doi.org/10.1152/japplphysiol.00249.2011

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Ma X, Egawa T, Oshima R, Kurogi E, Tanabe H, Tsuda S, Hayashi T.
Coptidis Rhizoma water extract stimulates 5’-AMP-activated protein kinase in rat skeletal muscles.
Chin J Nat Med. 2011;9(3):215–221.
https://doi.org/10.3724/SP.J.1009.2011.00215

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Egawa T, Hamada T, Ma X, Karaike K, Kameda N, Masuda S, Iwanaka N, Hayashi T.
Caffeine activates preferentially α1-isoform of 5’AMP-activated protein kinase in rat skeletal muscle.
Acta Physiol. 2011;201(2):227–238.
https://doi.org/10.1111/j.1748-1716.2010.02169.x

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2010

Ma X, Egawa T, Kimura H, Karaike K, Masuda S, Iwanaka N, Hayashi T.
Berberine-induced activation of 5’-adenosine monophosphate-activated protein kinase and glucose transport in rat skeletal muscles.
Metabolism. 2010;59(11):1619–1627.
https://doi.org/10.1016/j.metabol.2010.03.009

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Iwanaka N, Egawa T, Satoubu N, Karaike K, Ma X, Masuda S, Hayashi T.
Leucine modulates contraction- and insulin-stimulated glucose transport and upstream signaling events in rat skeletal muscle.
J Appl Physiol. 2010;108(2):274–282.
https://doi.org/10.1152/japplphysiol.00420.2009

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2009

Egawa T, Hamada T, Kameda N, Karaike K, Ma X, Masuda S, Iwanaka N, Hayashi T.
Caffeine acutely activates 5’adenosine monophosphate-activated protein kinase and increases insulin-independent glucose transport in rat skeletal muscles.
Metabolism. 2009;58(11):1609–1617.
https://doi.org/10.1016/j.metabol.2009.05.013

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Masuda S, Hayashi T, Egawa T, Taguchi S.
Evidence for differential regulation of lactate metabolic properties in aged and unloaded rat skeletal muscle.
Exp Gerontol. 2009;44(4):280–288.
https://doi.org/10.1016/j.exger.2008.12.003

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Ma X, Iwanaka N, Masuda S, Karaike K, Egawa T, Hamada T, Toyoda T, Miyamoto L, Nakao K, Hayashi T.
Morus alba leaf extract stimulates 5'-AMP-activated protein kinase in isolated rat skeletal muscle.
J Ethnopharmacol. 2009;122(1):54–59.
https://doi.org/10.1016/j.jep.2008.11.022